Here's a long NYT Magazine article by James Vlahos, "The Super Bowl of Sports Gambling," profiling a dozen or so competitors in a giant Las Vegas contest to see who can beat the point spread the most over the 2013 NFL season, picking at least five games per week. The winner was a Chicago yuppie who beat the point spread more than two-thirds of the time.
The article cites some opinion polls showing a surprisingly high degree of sports gambling among American women, but I have to imagine that's mostly office pools and other social betting. None of the intense football bettors in the article are women. If you go to a casino, you see plenty of older women hitting the slot machines hard, but having a serious sports gambling habit, whether betting against the point spread or playing fantasy football seriously for money, strikes me as about as all male of a phenomenon as anything in American life. But perhaps I'm wrong.